反应详情

温度

130 °C

Diethyl ethoxymethylenemalonate was added to 3,4-difluoroaniline at ambient temperature and the mixture was stirred at 130° C. for 17 hours. After diphenyl ether was additionally added to the reaction mixture, stirring was done at 260° C. for one hour. A solid obtained by leaving the reaction mixture to stand for cooling to ambient temperature was filtered, to obtain ethyl 6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate.

1. stirringstirring
2. waitwas done at 260° C. for one hour
3. customA solid obtained
4. customby leaving the reaction mixture
5. temperaturefor cooling to ambient temperature
6. filtrationwas filtered