Potassium Carbonate → HCID 23117800, compound

HRID 1724709Notes

Reaction equation

HRID 1724709 reaction equation
C(=O)([O-])[O-].[K+].[K+].I[CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.[F:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[F:24])[N:20]=[N:19][C:18]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[C:17]2[OH:30]>CN(C=O)C>[CH:8]1([N:20]2[C:21]3[C:16](=[CH:15][C:14]([F:13])=[C:23]([F:24])[CH:22]=3)[C:17](=[O:30])[C:18]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[N:19]2)[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 73784IodocyclopentaneHCID 178470455HCID 178470455, compound

Product 1

HCID 23117800HCID 23117800, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Potassium carbonate and iodocyclopentane were added to a DMF solution of ethyl 6,7-difluoro-4-hydroxycinnoline-3-carboxylate, for stirring at 80° C. for 40 minutes, to obtain ethyl 1-cyclopentyl-6,7-difluoro-4-oxo-1,4-dihydrocinnoline-3-carboxylate.

Sources & evidence

ORD record
ord-774d76747ecf4369a87f54d605926640
Source dataset
uspto-grants-2009_02
Patent number
US07488739B2

Reaction notes

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