反应详情

Under nitrogen, 4-acetylphenyl 3-tert-butoxycarbonyl-2,2-dimethyloxazolidine-4-(R)-carboxylate (440 mg) is dissolved in dichloromethane (15 ml), and trifluoroacetic acid (TFA; 8 ml) is added. After being subjected to agitation for 1 hour, the reaction mixture is concentrated and ether is added. The formed precipitate is filtered, then vacuum dried to obtain the desired product as a white powder (280 mg). Melting point: 115-118° C.

1. concentrationthe reaction mixture is concentrated
2. additionether is added
3. filtrationThe formed precipitate is filtered
4. customvacuum dried