Ammonium formate → HCID 46203238, compound

HRID 1724866Notes

Reaction equation

HRID 1724866 reaction equation
Cl[C:2]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]2[C:4](=[CH:5][C:6]([C:14]3[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:7][CH:8]=2)[N:3]=1.C([O-])=O.[NH4+]>[Pd].CO>[CH3:13][O:12][C:10]1[C:9]2[C:4](=[CH:5][C:6]([C:14]3[C:19]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:7][CH:8]=2)[N:3]=[CH:2][CH:11]=1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 46203237HCID 46203237, compound

Product 1

HCID 46203238HCID 46203238, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Stir a mixture of 2-chloro-4-methoxy-7-[3-(trifluoromethyl)pyridin-2-yl]quinoline (111 mg), ammonium formate (190 mg), 10% palladium on carbon (30 mg) in methanol (10 mL) at room temperature for 2 hours. Cool, filter through Celite and evaporate to give the title compound.

Workup

  1. temperatureCool
  2. filtrationfilter through Celite
  3. customevaporate

Sources & evidence

ORD record
ord-fbfa73388a504b9697dcc56d29e9b50a
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

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