Phosphorus oxychloride → HCID 46203239, compound

HRID 1724868Notes

Reaction equation

HRID 1724868 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[C:4]([C:9]2[CH:18]=[C:17]3[C:12]([C:13](O)=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[N:5][CH:6]=[CH:7][CH:8]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:13]1[C:12]2[C:17](=[CH:18][C:9]([C:4]3[C:3]([C:2]([F:21])([F:20])[F:1])=[CH:8][CH:7]=[CH:6][N:5]=3)=[CH:10][CH:11]=2)[N:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178516376HCID 178516376, compound

Product 1

HCID 46203239HCID 46203239, compound

Procedure

Reflux 7-[3-(trifluoromethyl)pyridin-2-yl]quinolin-4-ol (145 mg) for 2 hours in POCl3 (2 mL). Evaporate the solvent, then carefully neutralize with saturated NaHCO3, and extract with EtOAc. Dry-over Na2SO4, concentrate under vacuum to obtain the title compound.

Workup

  1. customEvaporate the solvent
  2. extractionextract with EtOAc
  3. concentrationDry-over Na2SO4, concentrate under vacuum

Sources & evidence

ORD record
ord-be336268e8c946c8846801c5a4c5b613
Source dataset
uspto-grants-2009_02
Patent number
US07488740B2

Reaction notes

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