Triethylamine → HCID 57423682, compound

HRID 1725164Notes

Reaction equation

HRID 1725164 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH2:4][N:5]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][CH:7]=[C:6]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1.[CH3:24][C:25]1[O:29][N:28]=[C:27]([C:30](Cl)=[O:31])[CH:26]=1.C(N(CC)CC)C>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:23])[CH2:4][N:5]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][CH:7]=[C:6]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:30]([C:27]2[CH:26]=[C:25]([CH3:24])[O:29][N:28]=2)=[O:31])[CH:17]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27368945-Methylisoxazole-3-carbonyl chlorideHCID 57423680HCID 57423680, compound

Product 1

HCID 57423682HCID 57423682, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [2-(3-amino-phenyl)-5-phenyl-pyrrol-1-yl]-acetic acid methyl ester (0.1 mmol) in DCM (2 mL) is added 5-methyl-isoxazole-3-carbonyl chloride (0.1 mmol) and triethylamine (0.02 mmol). The reactions are agitated at room temperature over night. The solvent is removed under vacuum and the residues are subsequently dried under high vacuum at 50° C. for 2 h.

Workup

  1. customThe solvent is removed under vacuum
  2. customthe residues are subsequently dried under high vacuum at 50° C. for 2 h.

Sources & evidence

ORD record
ord-c2ff7bb72bc24bd1baf804dccfeef0e6
Source dataset
uspto-grants-2009_02
Patent number
US07488832B2

Reaction notes

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