HRID1725287

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID12734

Diisopropylcarbodiimide

C7H14N2

结构：NCc1ccc(C2C(CCC(O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1

HCID22252032

未命名化合物

结构：O=C(O)COCCOCCOCC(=O)NCCOCCOCC(=O)C(O)C(O)C(O)C(O)CO

HCID22252092

未命名化合物

HCID178418300

未命名化合物

PRODUCTS

生成物

结构：O=C(CCCCCNC(=O)C(O)C(O)C(O)C(O)CO)Nc1cccc(C2C(CCC(O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)c1

HCID22252088

未命名化合物

PROCEDURE

实验过程

28 is prepared similarly to 18 starting from 62 mg of 4-(4-aminomethylphenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one, 76 mg of {2-[2-({2-[2-(3,4,5,6,7-pentahydroxy-2-oxoheptyloxy)ethoxy]ethylcarbamoyl}methoxy)-ethoxy]ethoxy}acetic acid 17, 57 μl of diisopropylcarbodiimide and 40 mg of hydroxybenzotriazole in 2 ml of dimethylformamide. This gives 19:

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-149c55a4cec746158c6af589c97e027e
来源数据集: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07488829B2
来源说明: uspto-grants-2009_02

反应 SMILES

NC[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:11](=[O:20])[CH:10]2[CH2:21][CH2:22][CH:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[OH:24])=[CH:5][CH:4]=1.[OH:32][CH:33]([CH:58]([OH:65])[CH:59]([OH:64])[CH:60]([OH:63])[CH2:61][OH:62])[C:34](=[O:57])COCCOCCNC(COCCOCCOCC(O)=O)=O.C(N=C=NC(C)C)(C)C.O[C:76]1[C:84]2[N:83]=N[NH:81][C:80]=2[CH:79]=[CH:78][CH:77]=1.CN(C)C=[O:88]>>[F:19][C:16]1[CH:15]=[CH:14][C:13]([N:12]2[C:11](=[O:20])[CH:10]([CH2:21][CH2:22][CH:23]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[OH:24])[CH:9]2[C:6]2[CH:7]=[C:8]([NH:83][C:84]([CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][NH:81][C:34](=[O:57])[CH:33]([OH:32])[CH:58]([OH:65])[CH:59]([OH:64])[CH:60]([OH:63])[CH2:61][OH:62])=[O:88])[CH:3]=[CH:4][CH:5]=2)=[CH:18][CH:17]=1