2,7-Naphthalenediol → HCID 86606151, compound

HRID 1725321Notes

Reaction equation

HRID 1725321 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([OH:12])=[CH:7][CH:8]=2)[CH:3]=1.[OH-].[K+].[CH3:15][N:16]([CH3:20])[C:17](Cl)=[S:18]>O.O1CCCC1>[CH3:15][N:16]([CH3:20])[C:17]([O:1][C:2]1[CH:3]=[C:4]2[C:9]([CH:8]=[CH:7][C:6]([O:12][C:17](=[S:18])[N:16]([CH3:20])[CH3:15])=[CH:5]2)=[CH:10][CH:11]=1)=[S:18]

Participants

6

Reactant 3

HCID 113972,7-NaphthalenediolHCID 14797Potassium HydroxideHCID 27871Dimethylthiocarbamoyl chloride

Product 1

HCID 86606151HCID 86606151, compoundYield 75.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
10 °C

Procedure

To a mixture containing 32 grams of 2,7-dihydroxynaphthalene and 26.3 grams of potassium hydroxide in 140 ml of water which had been cooled to 10° C. was slowly added 56.8 grams of dimethylthiocarbamoyl chloride in 88 ml of tetrahydrofuran. The temperature was maintained below 12° C. throughout the addition. The solid which formed was filtered, washed with water, reslurried in methanol and filtered to produce 50.2 grams of dimethyl-thiocarbamic acid O-(7-dimethylthiocarbamoyloxy-naphthalen-2-yl) ester. After drying this was placed in a round bottom flask and heated under a nitrogen atmosphere at 250° C. for 1.5 hours. The mixture was cooled and the solid recrystallized from ethyl acetate to give 17 grams of dimethyl-thiocarbamic acid S-(7-dimethylcarbamolysulfanyl-naphthalene-2-yl) ester. This was added to a mixture of 50 ml of ethanol and a solution of 22.4 grams of potassium in 32 mil of water, and then heated at reflux for 30 minutes. The mixture was cooled, diluted with 300 ml of water and acidified with hydrochloric acid. The solid which formed was filtered and dried yielding 8.5 grams of naphthalene-2,7-dithiol (9).

Workup

  1. temperatureThe temperature was maintained below 12° C. throughout the addition
  2. customThe solid which formed
  3. filtrationwas filtered
  4. washwashed with water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-2461ff5245994e2d9a5dbfd6c6b63baa
Source dataset
uspto-grants-2009_02
Patent number
US07491441B2

Reaction notes

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