反应详情

To a mixture of 10 g of 1,3-dibromopropan-2-ol, 5.0 ml of 3,4-dihydro-2H-pyran and 50 ml of chloroform was added a catalytic amount of p-toluenesulfonic acid monohydrate followed by stirring at room temperature for 3 hours. The reaction solution was concentrated, diluted with diethyl ether and washed with saturated sodium bicarbonate and brine. The resulting organic layer was dried over magnesium sulfate and filtered, and the filtrate was concentrated to give the title compound.

1. concentrationThe reaction solution was concentrated
2. additiondiluted with diethyl ether
3. washwashed with saturated sodium bicarbonate and brine
4. dry with materialThe resulting organic layer was dried over magnesium sulfate
5. filtrationfiltered
6. concentrationthe filtrate was concentrated