1H-Tetrazole, 5-chloro-1-phenyl- → 1-(1-Phenyl-1H-tetrazol-5-YL)piperazine

HRID 1725580Notes

Reaction equation

HRID 1725580 reaction equation
Cl[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[N:4][N:3]=1.[N:13]1(C(OC(C)(C)C)=O)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CN(C=O)C>[C:7]1([N:6]2[C:2]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:3][N:4]=[N:5]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 842621H-Tetrazole, 5-chloro-1-phenyl-HCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 38255781-(1-Phenyl-1H-tetrazol-5-YL)piperazine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Preparation took place by reacting 5-chloro-1-phenyl-1H-tetrazole with tert-butyl piperazine-1-carboxylate in DMF at 40° C.

Workup

  1. customPreparation
  2. customat 40° C.

Sources & evidence

ORD record
ord-cf8a911380a94912a6559661905a8255
Source dataset
uspto-grants-2009_02
Patent number
US07491729B2

Reaction notes

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