反应详情

温度

0 °C

Ethyl 2-mercaptoacetate is added to a solution of dimethylformamide (800 ml), 2-nitrobenzaldehyde (73 g, 0.48 mol) and potassium carbonate (80 g, 0.57 mol) cooled to 0° C., while the temperature is maintained at 0° C. After stirring for 24 hours, the mixture is poured into 2 l of water and this aqueous phase is extracted with ether. The ether phase is dried over sodium sulfate and concentrated. The crude product obtained is purified on a column of alumina (petroleum ether) to give 34 g (35%) of a yellow oil.

1. temperatureis maintained at 0° C
2. extractionthis aqueous phase is extracted with ether
3. dry with materialThe ether phase is dried over sodium sulfate
4. concentrationconcentrated
5. customThe crude product obtained
6. customis purified on a column of alumina (petroleum ether)