Lithium Hydroxide → HCID 68862480, compound

HRID 1726016Notes

Reaction equation

[CH2:1]([C:3]1[C:4]([O:31][CH3:32])=[C:5]([C:10]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:16])=[O:15])=[CH:11][CH:12]=1)[C:6]([O:8]C)=[O:7])[CH3:2].[Li+].[OH-]>>[CH2:1]([C:3]1[C:4]([O:31][CH3:32])=[C:5]([C:10]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:16])=[O:15])=[CH:11][CH:12]=1)[C:6]([OH:8])=[O:7])[CH3:2]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68863028HCID 68863028, compound

Product 1

HCID 68862480HCID 68862480, compound

Procedure

A mixture of Example 575A and Example 576A (0.10 g) was treated with LiOH according to the procedure of Example 385I, giving the title compound, 12.4 mg, and Example 576B, 42 mg. 1H NMR (DMSO-d6) δ 1.06 (t, 3H), 2.42 (q, 2H), 2.84 (t, 2H), 3.15 (t, 2H), 3.62 (s, 3H), 6.74 (d, 1H), 7.18-7.22 (m, 2H), 7.14-7.30 (m, 4H), 7.35 (t, 1H), 7.45 (d, 1H), 7.55 (t, 1H), 7.80 (d, 1H), 9.95 (s, 1H), 13.20 (br s, 1H); MS (ESI(−)) m/e 438 (M−H)−.

Sources & evidence

ORD record: ord-99d032d8b2144875b36ea21f3efbbf46
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07491718B2

Reaction notes

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