Hydrochloric Acid → HCID 136055970, compound

HRID 1726099Notes

Reaction equation

HRID 1726099 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:14][CH:15]=2)[C:10]([C:25]2[N:26](C(OC(C)(C)C)=O)[C:27]3[C:32]([CH:33]=2)=[CH:31][C:30]([O:34][CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)=[CH:29][CH:28]=3)=[N:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH2:18]([O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[NH:8][N:9]=[C:10]2[C:25]1[NH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][C:30]([O:34][CH2:35][CH2:36][N:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1)=[CH:29][CH:28]=2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57562498HCID 57562498, compound

Product 1

HCID 136055970HCID 136055970, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.0 g of 5-benzyloxy-3-[1-tert-butoxycarbonyl-5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]indazole-1-carboxylic acid tert-butyl ester are stirred at ambient temperature for 18 hours in 6 ml of a 4M hydrochloric acid solution in dioxane. The product is filtered through sintered glass, and rinsed with dioxane to obtain 692.4 mg of 5-benzyloxy-3-[5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-1H-indazole.

Workup

  1. filtrationThe product is filtered through sintered glass
  2. washrinsed with dioxane

Sources & evidence

ORD record
ord-280727d8d92a44fcb67b1a3e00629ea0
Source dataset
uspto-grants-2009_02
Patent number
US07491710B2

Reaction notes

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