Trifluoroacetic acid → HCID 136056001, compound

HRID 1726105Notes

Reaction equation

HRID 1726105 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:14][CH:15]=2)[C:10]([C:25]2[N:26](C(OC(C)(C)C)=O)[C:27]3[C:32]([CH:33]=2)=[CH:31][CH:30]=[C:29]([O:34][CH2:35][CH2:36][N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])[CH:28]=3)=[N:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:18]([O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[NH:8][N:9]=[C:10]2[C:25]1[NH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][CH:30]=[C:29]([O:34][CH2:35][CH2:36][N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])[CH:28]=2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68840237HCID 68840237, compound

Product 1

HCID 136056001HCID 136056001, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound {2-[2-(5-benzyloxy-1H-indazol-3-yl)-1H-indol-6-yloxy]ethyl}diethylamine is prepared in the following way: 390 mg of 5-benzyloxy-3-[1-tert-butoxycarbonyl-6-(2-diethylaminoethoxy)-1H-indol-2-yl]-indazole-1-carboxylic acid tert-butyl ester in solution in 5 ml of dichloromethane and 2 ml of trifluoroacetic acid are stirred at ambient temperature for 20 hours. The solvent is evaporated off under vacuum in a rotary evaporator to obtain 480 mg of {2-[2-(5-benzyloxy-1H-indazol-3-yl)-1-indol-6-yloxy]ethyl}diethylamine in the form of a trifluoroacetate salt.

Workup

  1. customThe solvent is evaporated off under vacuum in a rotary evaporator

Sources & evidence

ORD record
ord-7708641f1f5f4f2b93421a3a2680070a
Source dataset
uspto-grants-2009_02
Patent number
US07491710B2

Reaction notes

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