Diisopropylethylamine → HCID 86610852, compound

HRID 1726379Notes

Reaction equation

HRID 1726379 reaction equation
[C:1]1([C:7]2[S:8][C:9]([C:19]([OH:21])=O)=[C:10]([C:12]3C=CC(Cl)=CC=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3]C=1.CC[N:24](C(C)C)C(C)C.[CH3:31][CH:32]([NH2:46])[CH2:33][N:34]1[CH2:39][CH2:38][N:37]([C:40]2[N:45]=[CH:44][CH:43]=[CH:42][N:41]=2)[CH2:36][CH2:35]1>>[CH3:31][CH:32]([NH:46][C:19]([C:9]1[S:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][N:24]=2)=[N:11][C:10]=1[CH3:12])=[O:21])[CH2:33][N:34]1[CH2:35][CH2:36][N:37]([C:40]2[N:41]=[CH:42][CH:43]=[CH:44][N:45]=2)[CH2:38][CH2:39]1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 52845604-(4-Chlorophenyl)-2-phenyl-5-thiazolecarboxylic acidHCID 20075507HCID 20075507, compound

Product 1

HCID 86610852HCID 86610852, compound

Procedure

Proceeding as set forth in part (A) above, but substituting 4-methyl-2-pyridin-2-yl-thiazole-5-carboxylic acid for 2-phenyl-4-(4-chlorophenyl)-thiazole-5-carboxylic acid and substituting intermediate XIIId and DIEA (0.03 mL) for 1-methyl-2-(4-pyrimidin-2-yl-piperazin-1-yl)ethyl amine, the compound 2-(pyrid-2-yl)-4-methyl-thiazole-5-carboxylic acid [1-methyl-2-(4-pyrimidin-2-yl-piperazin-1-yl)-ethyl]-amide (compound 31) was prepared. M+H=424

Sources & evidence

ORD record
ord-6e2e13ab5c874854a173eabae600691c
Source dataset
uspto-grants-2009_02
Patent number
US07491821B2

Reaction notes

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