Hydrochloric Acid → HCID 68925675, compound

HRID 1726405Notes

Reaction equation

HRID 1726405 reaction equation
CON=[C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[C:14]([C:22]4[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=4)=[N:15][N:16]4[CH:21]=[CH:20][CH:19]=[N:18][C:17]=34)=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.Cl.[O:29]1CCOCC1>C(OCC)(=O)C>[N:25]1[CH:26]=[CH:27][C:22]([C:14]2[C:13]([C:9]3[CH:8]=[C:7]4[C:12](=[CH:11][CH:10]=3)[C:4](=[O:29])[CH2:5][CH2:6]4)=[C:17]3[N:18]=[CH:19][CH:20]=[CH:21][N:16]3[N:15]=2)=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86607282HCID 86607282, compound

Product 1

HCID 68925675HCID 68925675, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
100 °C

Procedure

To 5-(2-(pyridin-4-yl)pyrazolo[1.5-a]pyrimidin-3-yl)-2,3-dihydroinden-1-one O-methyl oxime (0.090 g; Example 7, Step 5) in 1.3 mL dioxane was added 1.3 mL 4M hydrochloric acid and the mixture was heated to 100° C. for 5 hours. The cooled reaction mixture was diluted with ethyl acetate, washed with 10% aqueous potassium carbonate, dried over sodium sulfate, filtered, and evaporated to yield 75 mg product as a yellow-brown-solid. This material was carried on without further purification.

Workup

  1. customThe cooled reaction mixture
  2. washwashed with 10% aqueous potassium carbonate
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-fba20325664647549310441bf4bd6cff
Source dataset
uspto-grants-2009_02
Patent number
US07491829B2

Reaction notes

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