反应详情

To a suspension of 4.0 g of 4-iodobenzoic acid (16.13 mmol) in 40 ml of CH2Cl2 there are added 3.65 ml of diisopropylethylamine (20.97 mmol) and then, after 10 minutes, 5.18 g of TBTU (16.13 mmol). After stirring for 10 minutes more, 1.60 ml of piperidine (16.13 mmol) are added and the reaction mixture is stirred overnight at ambient temperature. The reaction mixture is washed 3 times with water and then once with saturated NaCl. After drying (MgSO4) and evaporation under reduced pressure, the residue is chromatographed on silica (CH2Cl2/acetone 9/1) to yield the title product.

1. stirringthe reaction mixture is stirred overnight at ambient temperature
2. washThe reaction mixture is washed 3 times with water
3. customAfter drying
4. custom(MgSO4) and evaporation under reduced pressure
5. customthe residue is chromatographed on silica (CH2Cl2/acetone 9/1)