Hydrochloric Acid → HCID 23154471, compound

HRID 1726882Notes

Reaction equation

HRID 1726882 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28]5(OCC[O:29]5)[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[ClH:40]>>[ClH:40].[ClH:40].[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28](=[O:29])[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 231544778-[[4-[6-[4-(1-Methylethyl)-1-piperazinyl]-3-pyridinyl]phenyl]sulfonyl]-1,4-dioxa-8-azaspiro[4.5]decane

Product 1

HCID 23154471HCID 23154471, compound

Conditions

Temperature
80 °C

Procedure

A suspension of 400 mg of the product obtained in Step C (0.82 mmol) in 5 ml of 1N HCl is stirred for 1 hour at 80° C. After neutralisation of the reaction mixture using 10% NaHCO3, the precipitate is filtered off, washed with water and dried. The white solid is suspended in ethanol and dissolved by adding methanolic HCl. The solution is evaporated to dryness and the residue is taken up in an ethanol/ethyl ether mixture to yield the expected product after filtration.

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed with water
  3. customdried
  4. dissolutiondissolved
  5. additionby adding methanolic HCl
  6. customThe solution is evaporated to dryness

Sources & evidence

ORD record
ord-a666c67b36b64f4ea169e11abf46ad8a
Source dataset
uspto-grants-2009_02
Patent number
US07494994B2

Reaction notes

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