反应详情

3-(Trifluoromethyl) acetophenone (5.00 g, 26.6 mmol), paraformaldehyde (1.596 g, 2 eq.), dimethylamine hydrochloride (3.25 g, 1.5 eq.) were mixed together in 7 ml of EtOH, treated with 0.08 ml of 37% HCl, and heated to reflux for 5 h. Cooling down to ambient temperature, filtration and washing with tiny amounts of cold EtOH delivered 5.58 g of the title compound as white crystals of mp. 144-146° C. (dec.).

1. temperatureheated
2. temperatureto reflux for 5 h
3. washwashing with tiny amounts of cold EtOH