反应详情

160 mg (0.32 mmol) of the above prepared 3-{4-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-5,6,7,8-tetrahydro-naphthalen-1-yl}-propionic acid ethyl ester was dissolved in 5 ml of ethanol; 1.0 ml of 2N aqueous lithium hydroxide solution was added and the solution was heated to reflux for 1 hour. Then, the solution was cooled to room temperature and 1.0 ml of 2N aqueous hydrochloric acid was added. The white precipitated solid was filtered off, washed with water, and dried. 140 mg of the title product was thereby obtained as off-white solid.

1. temperaturethe solution was heated
2. temperatureto reflux for 1 hour
3. customThe white precipitated solid
4. filtrationwas filtered off
5. washwashed with water
6. customdried