Trifluoroacetic acid → HCID 68829433, compound

HRID 1727158Notes

Reaction equation

HRID 1727158 reaction equation
COC1C=CC(C[N:8](CC2C=CC(OC)=CC=2)[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N:17]3[CH2:21][CH:20]([C:22]4[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=5[C:37]#[N:38])[CH:23]=4)[CH2:19][C:18]3=[O:39])[N:12]=2)=[O:10])=CC=1.C(O)(C(F)(F)F)=O>>[C:37]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[O:30][C:24]1[CH:23]=[C:22]([CH:20]2[CH2:21][N:17]([C:13]3[N:12]=[C:11]([C:9]([NH2:8])=[O:10])[CH:16]=[CH:15][CH:14]=3)[C:18](=[O:39])[CH2:19]2)[CH:27]=[CH:26][C:25]=1[O:28][CH3:29])#[N:38]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68828139HCID 68828139, compound

Product 1

HCID 68829433HCID 68829433, compound

Conditions

Temperature
100 °C

Procedure

Crude product of 6-{4-[3-(2-cyanophenoxy)-4-methoxyphenyl]-2-oxo-pyrrolidin-1-yl}pyridine-2-carboxylic acid bis-(4-methoxy-benzyl)-amide was added to a TFA (0.5 mL) solution and heated to 100° C. for 8 h. After cooling down to r.t., the mixture was concentrated and purified by preparative LC-MS to provide the desired product.

Workup

  1. temperatureAfter cooling down to r.t.
  2. concentrationthe mixture was concentrated
  3. custompurified by preparative LC-MS

Sources & evidence

ORD record
ord-f116e8aeb6c3487b863be44509c5d36d
Source dataset
uspto-grants-2009_02
Patent number
US07495016B2

Reaction notes

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