Hydrochloric Acid → HCID 69058462, compound

HRID 1727200Notes

Reaction equation

HRID 1727200 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1.[ClH:22]>>[ClH:22].[NH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([CH2:8][S:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66570330HCID 66570330, compound

Product 1

HCID 69058462HCID 69058462, compound

Procedure

tert-Butyl 3-[(2-pyridinylsulfanyl)methyl]-1-piperidinecarboxylate (Preparation 51, 1.0 g, 3.2 mmol) in hydrogen chloride (4 M solution in dioxane, 8.1 ml) was stirred under nitrogen at room temperature. After 25 min a white solid precipitated out of solution. Diethyl ether was added and the reaction mixture was filtered and the solid washed with diethyl ether. The title compound was obtained as a solid (0.81 g, 100%).

Workup

  1. customAfter 25 min a white solid precipitated out of solution
  2. additionDiethyl ether was added
  3. filtrationthe reaction mixture was filtered
  4. washthe solid washed with diethyl ether

Sources & evidence

ORD record
ord-521b012fc2ad444fa3e04efcc3fa11e4
Source dataset
uspto-grants-2009_02
Patent number
US07494992B2

Reaction notes

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