2,6-Dipropylphenol → 2,6-Dipropyl4-propionylphenol

HRID 1727286Notes

Reaction equation

HRID 1727286 reaction equation
[C:1]([O-:5])(=O)[CH2:2][CH3:3].[Na+].[CH2:7]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][CH2:17][CH3:18])[C:11]=1[OH:19])[CH2:8][CH3:9]>OS(C(F)(F)F)(=O)=O>[CH2:16]([C:12]1[CH:13]=[C:14]([C:1](=[O:5])[CH2:2][CH3:3])[CH:15]=[C:10]([CH2:7][CH2:8][CH3:9])[C:11]=1[OH:19])[CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 811072,6-DipropylphenolHCID 2723816Sodium Propionate

Product 1

HCID 113108722,6-Dipropyl4-propionylphenol

Reagents, catalysts & solvents 1

HCID 62406Trifluoromethanesulfonic acidSolvent

Procedure

Sodium propanoate (0.88 g, 1.5 eq) and 2,6-dipropylphenol (1.09 g, 1.0 eq) were combined in Triflic Acid (5.0 g) as in Example 13, step 1. The resulting waxy solid was purified by chromatography on silica gel using ethyl acetate:hexanes:acetic acid (10:90:1) to give the titled phenol.

Workup

  1. customThe resulting waxy solid was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-3b0334179b264f1582ed15228403292d
Source dataset
uspto-grants-2009_02
Patent number
US07495020B2

Reaction notes

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