反应详情

To a solution of 5-(2-chloromethyl-4-pyridyl)-2-ethyl-4-(3-methylphenyl)-1,3-thiazole (0.20 g, 0.61 mmol) in pyrrolidine (0.5 mL) was stirred for 1 hour at 80° C. After cooling, to this was added an aqueous potassium carbonate solution, and extracted with ethyl acetate. The extracts were washed with brine, then, dried and concentrated. The residue was purified by alumina column chromatography (hexane-ethyl acetate=2:1). The resulting oil was made into a hydrochloride by using a solution of 4N-hydrogen chloride in ethyl acetate, and recrystallized from ethanol-isopropyl ether, to obtain a title compound (0.23 g, 85%).

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe extracts were washed with brine
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by alumina column chromatography (hexane-ethyl acetate=2:1)
7. customrecrystallized from ethanol-isopropyl ether