Lithium Hydroxide → HCID 23704465, compound

HRID 1727384Notes

Reaction equation

HRID 1727384 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH:11]([C:13]([O:15]CC)=[O:14])[N:10]=[C:9]2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])=[CH:4][CH:3]=1.[Li+:26].[OH-]>CO.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:12][CH:11]([C:13]([O-:15])=[O:14])[N:10]=[C:9]2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])=[CH:6][CH:7]=1.[Li+:26]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 21082128HCID 21082128, compound

Product 1

HCID 23704465HCID 23704465, compoundYield 125.1%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Part A: A mixture of ethyl 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-4,5-dihydro-1H-imidazole-4-carboxylate (3.97 g, 0.01 mol) in methanol/water is reacted with LiOH (1.3 gram, 0.054 mol) at room temperature for 16 hours. The resulting mixture is concentrated in vacuo to give crude lithium 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-4,5-dihydro-1H-imidazole-4-carboxylate (4.7 gram).

Workup

  1. concentrationThe resulting mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-c54492847b7e45ae9512c523d155bff0
Source dataset
uspto-grants-2009_02
Patent number
US07495108B2

Reaction notes

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