反应详情

To a solution of 2,3-dihydropyrano[3,2-e]isoindol-1(7H)-one (71) (500 mg, 2.67 mmol) in THF (35 ml) was added NaH (95%, 87 mg, 3.47 mmol) in portions. Resulting mixture was stirred for 40 min before adding MeSO2Cl by syringe. Stirring was continued for 1 hour. The solvent was removed in vacuo and the residue was portioned with CH2Cl2. The organic solution was washed with H2O, sat. NaCl and dried over Na2SO4. Concentration in vacuo gave the title compound (95) as a solid (490 mg, 69%). MS (ES) m/z 266.0.

1. customResulting mixture
2. stirringStirring
3. waitwas continued for 1 hour
4. customThe solvent was removed in vacuo
5. washThe organic solution was washed with H2O, sat. NaCl
6. dry with materialdried over Na2SO4
7. concentrationConcentration in vacuo