Hydrochloric Acid → HCID 69030132, compound

HRID 1727425Notes

Reaction equation

HRID 1727425 reaction equation
[ClH:1].[CH2:2]([N:6]([CH2:41][CH:42]([CH3:44])[CH3:43])[C:7]([C:9]1[CH:40]=[CH:39][C:12]2[N:13]([CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C)[C:14]([NH:16][C:17]3[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([O:27][CH3:28])[CH:18]=3)=[N:15][C:11]=2[CH:10]=1)=[O:8])[CH:3]([CH3:5])[CH3:4]>C(OCC)(=O)C>[ClH:1].[NH2:31][CH2:30][CH2:29][N:13]1[C:12]2[CH:39]=[CH:40][C:9]([C:7]([N:6]([CH2:2][CH:3]([CH3:4])[CH3:5])[CH2:41][CH:42]([CH3:44])[CH3:43])=[O:8])=[CH:10][C:11]=2[N:15]=[C:14]1[NH:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([O:27][CH3:28])[CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69027292HCID 69027292, compound

Product 1

HCID 69030132HCID 69030132, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A stream of dry HCl is passed through a solution of tert-butyl 2-{5-[(diisobutylamino)carbonyl]-2-[(3,4,5-trimethoxy phenyl)amino]-1H-benzimidazol-1-yl}ethylcarbamate (2.56 g, prepared according to the procedure described in Example A1, reaction diagram A) in ethyl acetate (100 ml), (100% ethyl acetate) cooled down to 0° C. until the TLC shows complete disappearance of the starting product. The resulting mixture is then evaporated under reduced pressure. The solid obtained is triturated in diethylether and filtered in order to produce the expected compound in the form of white crystals (2.25 g, 97% yield).

Workup

  1. customprepared
  2. customThe resulting mixture is then evaporated under reduced pressure
  3. customThe solid obtained
  4. customis triturated in diethylether
  5. filtrationfiltered in order

Sources & evidence

ORD record
ord-e9a795de1f034d50b23ccf4ee6fbc0f9
Source dataset
uspto-grants-2009_02
Patent number
US07495110B2

Reaction notes

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