反应详情

温度

100 °C

In a sealed pressure tube was added 4-bromo-2-(3-formylphenyl)-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine (1.6 mmol), 3-(4-nitrophenyl)-1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.7 mmol), N,N-dimethylformamide (15 mL), aqueous saturated sodium bicarbonate (4 mL) and tetrakis(triphenylphosphine)palladium(0) (0.09 mmol). The reaction was purged with nitrogen, capped, and stirred at 100° C. for 8 h. After cooling to room temperature, the reaction was concentrated under vacuum, taken up in ethyl acetate, washed with water, brine, dried over sodium sulfate, filtered, and evaporated to dryness under vacuum. Purification by silica gel flash chromatography (5-10% ethyl acetate/methylene chloride) gave the title compound as a yellow solid (81%). ESMS [M+H]+: 578.3

1. customThe reaction was purged with nitrogen
2. customcapped
3. temperatureAfter cooling to room temperature
4. concentrationthe reaction was concentrated under vacuum
5. washwashed with water, brine
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customevaporated to dryness under vacuum
9. customPurification by silica gel flash chromatography (5-10% ethyl acetate/methylene chloride)