Ethyl Acetate → HCID 69063286, compound

HRID 1727909Notes

Reaction equation

HRID 1727909 reaction equation
C(OCC)(=O)C.[C:7]([CH2:9][CH2:10][O:11][C:12]([C:14]1[CH:15]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=2)[C:16]([C:26]([O:28]CC2C=CC=CC=2)=[O:27])=[C:17]([CH2:21][O:22][CH2:23][CH2:24][Cl:25])[NH:18][C:19]=1[CH3:20])=[O:13])#[N:8]>[H][H].[C].[Pd]>[C:7]([CH2:9][CH2:10][O:11][C:12]([C:14]1[CH:15]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=2)[C:16]([C:26]([OH:28])=[O:27])=[C:17]([CH2:21][O:22][CH2:23][CH2:24][Cl:25])[NH:18][C:19]=1[CH3:20])=[O:13])#[N:8]

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 69074752HCID 69074752, compound

Product 1

HCID 69063286HCID 69063286, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 178418361HCID 178418361, compoundSolvent

Procedure

5 ml of ethyl acetate and 10% palladium carbon were added to 340 mg (0.640 mmol) of 2-(2-chloroethoxy) methyl-4-(3-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyanoethyl) ester. The obtained solution was stirred at room temperature in hydrogen atmosphere under normal pressure for 8 hours. After filtering the reaction mixture, the filtrate was evaporated under reduced pressure to obtain the title compound.

Workup

  1. filtrationAfter filtering the reaction mixture
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a029e48d196141d39b0646b54456613b
Source dataset
uspto-grants-2009_02
Patent number
US07494989B2

Reaction notes

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