Acetone → HCID 12694356, compound

HRID 1728047Notes

Reaction equation

HRID 1728047 reaction equation
[CH3:1][CH2:2][CH:3](P(OCC)(OCC)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[H-].[Na+].[CH3:19][C:20]([CH3:22])=O>C(COC)OC>[CH2:7]([O:6][C:4](=[O:5])[C:3]([CH2:2][CH3:1])=[C:20]([CH3:22])[CH3:19])[CH3:8]

Participants

5

Reactant 3

HCID 180AcetoneHCID 24758Sodium hydrideHCID 229053Ethyl 2-(diethoxyphosphoryl)butanoate

Product 1

HCID 12694356HCID 12694356, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

In a manner similar to the method described in example 102a, triethyl 2-phosphonobutyrate (25.2 g, 0.1 mol) was reacted with NaH (2.64 g, 0.11 mol), and then acetone (5.8 g, 0.1 mol) in dimethoxyethane to give 2-ethyl-3-methyl-but-2-enoic acid ethyl ester as colorless oil (Yield: 11.4 g, 73%).

Sources & evidence

ORD record
ord-e85e7df7ec7841788a5116ae30c0124e
Source dataset
uspto-grants-2009_02
Patent number
US07495007B2

Reaction notes

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