Potassium Carbonate → HCID 19017939, compound

HRID 1728370Notes

Reaction equation

HRID 1728370 reaction equation
[C:1]([O-:4])([O-:3])=[O:2].[K+].[K+].O[C:8]1[CH:9]=[C:10]([NH:14][C:15](=[O:19])[C:16]([CH3:18])=[CH2:17])[CH:11]=[CH:12][CH:13]=1>O1CCCC1>[C:16]([O:2][C:1]([O:4][C:8]1[CH:9]=[C:10]([NH:14][C:15](=[O:19])[C:16]([CH3:18])=[CH2:17])[CH:11]=[CH:12][CH:13]=1)=[O:3])([CH3:18])([CH3:17])[CH3:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21225962HCID 21225962, compound

Product 1

HCID 19017939HCID 19017939, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

K2CO3 (50 g) is added to a solution of 40.0 g (0.225 mol) of N-(3-hydroxyphenyl)methacrylamide in tetrahydrofuran (THF). A solution of 54.2 g (0.249 mol) of di-tert-butyl pyrocarbonate (di-tert-butyl dicarbonate) in THF is then added dropwise at room temperature while stirring. The reaction is complete after a few hours. The reaction mixture is poured onto ice and extracted with ethyl acetate, the organic phase is dried and the solvent is distilled off. A white crystalline product is obtained which is recrystallized from diisopropyl ether.

Workup

  1. waitThe reaction is complete after a few hours
  2. additionThe reaction mixture is poured onto ice
  3. extractionextracted with ethyl acetate
  4. customthe organic phase is dried
  5. distillationthe solvent is distilled off
  6. customA white crystalline product is obtained which
  7. customis recrystallized from diisopropyl ether

Sources & evidence

ORD record
ord-5e22028ef7c740aeacc4d81227d6dddc
Source dataset
uspto-grants-1994_07
Patent number
US05326840

Reaction notes

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