HCID 19017496, compound → HCID 10481928, compound

HRID 1728378Notes

Reaction equation

HRID 1728378 reaction equation
CC([O:5][C:6](=[O:42])[CH:7]([NH:25][CH:26]([C:31]([NH:33][CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1)=[O:32])[CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:8][CH2:9][N:10]1[C:18](=[O:19])[C:17]2[CH:16]=[C:15]3[CH:20]=[CH:21][CH:22]=[CH:23][C:14]3=[CH:13][C:12]=2[C:11]1=[O:24])(C)C>C(O)(C(F)(F)F)=O>[O:24]=[C:11]1[C:12]2[CH:13]=[C:14]3[CH:23]=[CH:22][CH:21]=[CH:20][C:15]3=[CH:16][C:17]=2[C:18](=[O:19])[N:10]1[CH2:9][CH2:8][C@@H:7]([NH:25][C@H:26]([C:31]([NH:33][CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1)=[O:32])[CH2:27][CH:28]([CH3:30])[CH3:29])[C:6]([OH:42])=[O:5]

Participants

3

Reactant 1

HCID 19017496HCID 19017496, compound

Product 1

HCID 10481928HCID 10481928, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

240 mg of 4-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)-2-[[3-methyl-1-[[(2-morpholin-4-yl-ethyl)amino]carbonyl]butyl]amino]-butanoic acid-1,1-dimethylethyl ester from part (A), was dissolved in TFA:H20 (9:1) and allowed to stand for 20 h. The solvents were removed by evaporation, and the resulting oil was purified by reverse phase H.P.L.C. The solvents were removed by lyopholization to give the title compound as a white solid; 145 mg.

Workup

  1. customThe solvents were removed by evaporation
  2. customthe resulting oil was purified by reverse phase H.P.L.C
  3. customThe solvents were removed by lyopholization

Sources & evidence

ORD record
ord-18fbfe8340ed4d06aa50cc99352cb1a6
Source dataset
uspto-grants-1994_07
Patent number
US05326760

Reaction notes

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