反应详情

A mixture of 3-Benzamidoindole-2-carboxamide (276 mg), sodium hydride (5 mg) and ethanol (5 mL) was refluxed for 2 h. The reaction mixture was quenched with saturated ammonium carbonate and the product was extracted with methylene chloride. After drying over magnesium sulfate, the solvent was removed in vacuo and the residue was triturated with ether to afford 4-Hydroxy-2-phenyl-5H-indolo[3,2-d]pyrimidine (Compound 2) as a white solid.

1. temperaturewas refluxed for 2 h
2. customThe reaction mixture was quenched with saturated ammonium carbonate
3. extractionthe product was extracted with methylene chloride
4. dry with materialAfter drying over magnesium sulfate
5. customthe solvent was removed in vacuo
6. customthe residue was triturated with ether