HCID 19018239, compound → HCID 19018231, compound

HRID 1728447Notes

Reaction equation

HRID 1728447 reaction equation
[CH3:1][C:2]1([CH2:8][O:9][C:10]2[CH:24]=[CH:23][C:13]([CH2:14][P:15](=[O:22])([O:19]CC)[O:16]CC)=[CH:12][CH:11]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>Cl>[CH3:1][C:2]1([CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][P:15](=[O:16])([OH:22])[OH:19])=[CH:23][CH:24]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 19018239HCID 19018239, compound

Product 1

HCID 19018231HCID 19018231, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution 0.7 g (2.0 mmol) of diethyl 4-[((1methyl)cyclohexyl)methoxy]benzylphosphonate and 10 ml of concentrated hydrochloric acid was refluxed for 24 hours. The reaction was cooled to room temperature, filtered and the solids were washed with water. The solids were recrystallized from EtOAc/cyclohexane to give 0.4 g of the product; m.p. 170°-172° C.

Workup

  1. filtrationfiltered
  2. washthe solids were washed with water
  3. customThe solids were recrystallized from EtOAc/cyclohexane

Sources & evidence

ORD record
ord-c4afa89448764f9bb7d7a4d861f377b1
Source dataset
uspto-grants-1994_07
Patent number
US05326905

Reaction notes

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