HCID 67842554, compound → HCID 19016526, compound

HRID 1728599Notes

Reaction equation

HRID 1728599 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10]N=C(OCC)C(=O)CCC)=[CH:6][CH:5]=1)([O-:3])=[O:2]>Cl>[CH2:5]([C:4]1[C:6]2[C:7](=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[NH:10][CH:9]=1)[CH3:6]

Participants

3

Reactant 1

HCID 67842554HCID 67842554, compound

Product 1

HCID 19016526HCID 19016526, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The 4-nitrophenylhydrazone of ethyl 2-oxopentanoate (D29) (0.72 g, 2.60 mM) was heated to reflux for 16 h in concentrated hydrochloric acid. After cooling to room temperature the precipitated solid was filtered off. Chromatography on silica using dichloromethane as eluant gave the title compound as a yellow solid (0.22 g; 45%).

Workup

  1. filtrationwas filtered off

Sources & evidence

ORD record
ord-15b103780a3c45b68d45661a388de054
Source dataset
uspto-grants-1994_07
Patent number
US05328922

Reaction notes

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