1-Chloroethyl chloroformate → HCID 131718545, compound

HRID 1728657Notes

Reaction equation

HRID 1728657 reaction equation
Cl.[CH3:2][N:3]([CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][N:13](CC(C)CC)[CH2:12][C@H:11]2[CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)=[CH:6][CH:5]=1.[Cl:34]C(OC(Cl)C)=O.Cl.C1OC2C=CC(OC[C@H]3[C@H](C4C=CC([N+]([O-])=O)=CC=4)CCNC3)=CC=2O1>ClCCCl>[ClH:34].[CH3:2][N:3]([CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[CH2:21][O:22][C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:27][CH:28]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 5213051-Chloroethyl chloroformateHCID 131718534HCID 131718534, compoundHCID 131718539HCID 131718539, compound

Product 1

HCID 131718545HCID 131718545, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Was prepared from compound (13) (3 g) and 1-chloroethyl chloroformate (1 g) in dry 1,2-dichloroethane (50 ml) as described for compound (6 ). Yield 62%. M.p. 195.5°-199.6° C. (d).

Sources & evidence

ORD record
ord-241f5516565e46f7b72745003753b04c
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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