Oxalyl chloride → 3-(1,1-Dimethylethyl)-4-(tetradecyloxy)benzoyl chloride

HRID 1728817노트

반응식

HRID 1728817 반응식
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:8](O)=[O:9])([CH3:4])[CH3:3].C(Cl)(=O)C([Cl:32])=O>C(Cl)Cl.CN(C)C=O>[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:8]([Cl:32])=[O:9])([CH3:4])[CH3:3]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 19015074HCID 19015074, 화합물

생성물 1

HCID 190153703-(1,1-Dimethylethyl)-4-(tetradecyloxy)benzoyl chloride수율 9.9%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 30.0 g of product from Example 32 in 300 ml of methylene chloride and 10 drops of dimethylformamide is added, dropwise, 14.62 g of oxalyl chloride. The reaction is stirred at room temperature for 18 hours and concentrated in vacuo. The residue is dissolved in diethyl ether, filtered through diatomaceous earth and concentrated to give 3.12 g of the desired product as yellow crystals.

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue is dissolved in diethyl ether
  3. filtrationfiltered through diatomaceous earth
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8f3874afe6624c0c93388888001e7593
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05328921

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