Iodoethane → 1-Ethyl-2-[2-[[[4-(hexadecyloxy)phenoxy]acetyl]amino]ethyl]pyridinium iodide

HRID 1728871Notes

Reaction equation

HRID 1728871 reaction equation
[CH2:1]([O:17][C:18]1[CH:36]=[CH:35][C:21]([O:22][CH2:23][C:24]([NH:26][CH2:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=2)=[O:25])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[CH2:37]([I:39])[CH3:38]>>[I-:39].[CH2:37]([N+:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[CH2:28][CH2:27][NH:26][C:24](=[O:25])[CH2:23][O:22][C:21]1[CH:20]=[CH:19][C:18]([O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:36][CH:35]=1)[CH3:38]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 197646782-[4-(Hexadecyloxy)phenoxy]-N-[2-(2-pyridinyl)ethyl]acetamide

Product 1

HCID 190159391-Ethyl-2-[2-[[[4-(hexadecyloxy)phenoxy]acetyl]amino]ethyl]pyridinium iodideYield 81.4%

Procedure

The title compound is prepared by the procedure of Example 8, using 0.50 g of product from Example 92, 7.85 g of ethyl iodide and heating the mixture at 110°-120° C. for 26 hours. The residue is recrystallized from methyl alcohol to give 0.535 g of the desired product.

Workup

  1. customThe title compound is prepared by the procedure of Example 8
  2. temperatureheating the mixture at 110°-120° C. for 26 hours
  3. customThe residue is recrystallized from methyl alcohol

Sources & evidence

ORD record
ord-6a092d357ec44627b8e3a4ba1d06c903
Source dataset
uspto-grants-1994_07
Patent number
US05328921

Reaction notes

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