反应详情

A mixture of 12.0 g of 3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester, 11.15 g of 1-bromodecane, 9.95 g of potassium carbonate, 0.797 g of potassium iodide and 100 ml of 2-butanone is heated at reflux temperature for 40 hours. The reaction is cooled, filtered and the filtrate concentrated in vacuo. The residue is purified by chromatography (silica gel: 0-3% ethyl acetate/hexane) to give 18.49 g of the desired product as a light yellow oil.

1. temperatureis heated
2. temperatureat reflux temperature for 40 hours
3. temperatureThe reaction is cooled
4. filtrationfiltered
5. concentrationthe filtrate concentrated in vacuo
6. customThe residue is purified by chromatography (silica gel: 0-3% ethyl acetate/hexane)