HRID1728897

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6340

Ethane, iodo-

C2H5I

反应SMILES：CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccccn2)C(C)=O)cc1OC

HCID10097364

未命名化合物

PRODUCTS

产物

反应SMILES：CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CC)C(C)=O)cc1OC.[I-]

HCID10394507

未命名化合物

收率 75.3%

CONDITIONS

反应条件

温度: 105 °C

PROCEDURE

实验过程

A mixture of 1.01 g of product from Example 49 and 15.83 g of ethyl iodide is heated at 105° C. for 23 hours. The reaction is concentrated in vacuo and triturated with diethyl ether to give 1.0 g of the desired product as yellow crystals.

WORKUP

后处理

concentrationThe reaction is concentrated in vacuo
customtriturated with diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6d998697ed45442faa0bdf5274635f7c
来源数据集: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05328921
来源说明: uspto-grants-1994_07

反应SMILES

[C:1]([N:4]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1)[C:5](=[O:29])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:8]([O:27][CH3:28])[CH:7]=1)(=[O:3])[CH3:2].[CH2:37]([I:39])[CH3:38]>>[I-:39].[C:1]([N:4]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N+:32]=1[CH2:37][CH3:38])[C:5](=[O:29])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:8]([O:27][CH3:28])[CH:7]=1)(=[O:3])[CH3:2]