Potassium Permanganate → HCID 13451547, compound

In a stream of nitrogen gas, 3.33 g of (1S, 6R)-1-methoxycarbonyl-6-methylcyclohex-3-ene was dissolved in 100 ml of cyclohexane, and the solution was added to a aqueous solution prepared by dissolving 13.5 g of potassium permanganate and 1.39 g of tetrabutylammonium bromide in 100 ml of H2O. The mixture was vigorously stirred for 4 hours at room temperature. To the reaction mixture was added 10 g of sodium hydrogen-sulfate, and the precipitate was filtered off. After the cyclohexane layer of the filtration was separated, and the water layer was adjusted to have a pH of 3 by concentrated hydrochloric acid, the water layer was extracted by ethyl acetate-tetrahydrofuran (1:1). The cyclohexane layer and the extraction were combined, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under a reduced pressure. To the residue, 12.5 ml of acetic anhydride and 0.825 g of sodium acetate were added, and the mixture was stirred for 1 hour at 130° C. After being cooled by air, the precipitate was filtered off, and the filtrate was concentrated under a reduced pressure. The residue was taken up into ethyl acetate, and the insoluble material was filtered off, followed by concentration of the filtrate under a reduced pressure. The residue was distilled under a reduced pressure, and thus 1.35 g of (3S, 4R)-3-methoxycarbonyl-4-methylcyclopentanone was obtained.

1. additionthe solution was added to a aqueous solution
2. customprepared
3. filtrationthe precipitate was filtered off
4. filtrationAfter the cyclohexane layer of the filtration
5. customwas separated
6. extractionthe water layer was extracted by ethyl acetate-tetrahydrofuran (1:1)
7. extractionThe cyclohexane layer and the extraction
8. dry with materialdried over anhydrous magnesium sulfate
9. filtrationAfter filtration
10. concentrationthe filtrate was concentrated under a reduced pressure
11. additionTo the residue, 12.5 ml of acetic anhydride and 0.825 g of sodium acetate were added
12. stirringthe mixture was stirred for 1 hour at 130° C
13. temperatureAfter being cooled by air
14. filtrationthe precipitate was filtered off
15. concentrationthe filtrate was concentrated under a reduced pressure
16. filtrationthe insoluble material was filtered off
17. distillationThe residue was distilled under a reduced pressure

ORD record

ord-34c96f07b91c4577895230fcef65d208

Source dataset

uspto-grants-1994_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05329042