Trifluoroacetic acid → HCID 19013273, compound

HRID 1729026Notes

Reaction equation

HRID 1729026 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH:39]([CH3:41])[CH3:40])=[C:6]([CH:38]=1)[O:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]2[N:24]=[C:23]([C:25]([NH:27][CH2:28][CH2:29][NH:30]C(=O)OC(C)(C)C)=[O:26])[CH:22]=[CH:21][N:20]=2)[CH2:11][CH2:10]1.FC(F)(F)C(O)=O>ClCCl>[NH2:30][CH2:29][CH2:28][NH:27][C:25]([C:23]1[CH:22]=[CH:21][N:20]=[C:19]([NH:18][CH2:17][CH2:16][CH2:15][N:12]2[CH2:13][CH2:14][CH:9]([CH2:8][O:7][C:6]3[CH:38]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=3[CH:39]([CH3:41])[CH3:40])[CH2:10][CH2:11]2)[N:24]=1)=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19013271HCID 19013271, compound

Product 1

HCID 19013273HCID 19013273, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.8 g (4.92 mmol) of 1,1-dimethylethyl 2-[[[2-[[3-[4-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]piperidin-1-yl]propyl]amino]pyrimidin-4-yl]carbonyl]amino]ethylcarbamate in solution in 20 ml of dichloromethane are introduced into a 0.25 l round-bottomed flask, 20 ml of trifluoroacetic acid are then added and the mixture is heated at reflux for 5 h.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 5 h.

Sources & evidence

ORD record
ord-4a78e38f55c14350a028487555445368
Source dataset
uspto-grants-1994_07
Patent number
US05330985

Reaction notes

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