Hydrochloric Acid → HCID 15233815, compound

HRID 1729028Notes

Reaction equation

HRID 1729028 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([OH:27])[CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24]([NH2:26])=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:10][CH2:9]2)[CH:7]=1.Cl>CO>[NH2:26][C:24]([C:22]1[CH:21]=[CH:20][N:19]=[C:18]([NH:17][CH2:16][CH2:15][NH:26][C:24]([C:22]2[CH:21]=[CH:20][N:19]=[C:18]([NH:17][CH2:16][CH:15]([OH:27])[CH2:14][N:11]3[CH2:10][CH2:9][N:8]([C:6]4[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=4[O:28][CH3:29])[CH2:13][CH2:12]3)[N:23]=2)=[O:25])[N:23]=1)=[O:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9802263HCID 9802263, compound

Product 1

HCID 15233815HCID 15233815, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

4.7 g. (11.16 mmol) of (±)-2-[[3-[4-(5-chloro-2-methoxyphenyl) piperazin-1-yl]-2-hydroxypropyl]amino]pyrimidine-4-carboxamide and 450 ml of methanol are introduced into a 1 l round-bottomed flask, a stream of gaseous hydrochloric acid is passed through for a few minutes and the mixture is heated at the reflux temperature of the methanol for 2 h.

Workup

  1. customis passed through for a few minutes

Sources & evidence

ORD record
ord-7a549fd1fcc640f2a177e6e03cadf65c
Source dataset
uspto-grants-1994_07
Patent number
US05330985

Reaction notes

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