Potassium Carbonate → HCID 15233815, compound

HRID 1729029Notes

Reaction equation

HRID 1729029 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][CH:15]([OH:32])[CH2:16][N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=3[O:30][CH3:31])[CH2:19][CH2:18]2)[N:8]=1)=[O:6].Cl[C:34]1[N:39]=[C:38]([C:40]([NH2:42])=[O:41])[CH:37]=[CH:36][N:35]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[NH2:42][C:40]([C:38]1[CH:37]=[CH:36][N:35]=[C:34]([NH:1][CH2:2][CH2:3][NH:4][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][CH:15]([OH:32])[CH2:16][N:17]3[CH2:22][CH2:21][N:20]([C:23]4[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=4[O:30][CH3:31])[CH2:19][CH2:18]3)[N:8]=2)=[O:6])[N:39]=1)=[O:41]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2470282-Chloropyrimidine-4-carboxamideHCID 19013283HCID 19013283, compound

Product 1

HCID 15233815HCID 15233815, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2.32 g (4.96 mmol) of (±)-N-(2-aminoethyl)-2-[[3-[4-(5-chloro-2-methoxyphenyl) piperazin-1-yl]-2-hydroxypropyl]amino]pyrimidine-4-carboxamide, 0.8 g (5.1mmol) of 2-chloropyrimidine-4-carboxamide and 1 g (7.2 mmol) of potassium carbonate are introduced, under an argon atmosphere, into 150 ml of acetonitrile in a 0.5 l round-bottomed flask and the mixture is heated at reflux for 17 h.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 17 h.

Sources & evidence

ORD record
ord-82783f80602247cca87d98610afbc936
Source dataset
uspto-grants-1994_07
Patent number
US05330985

Reaction notes

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