Saccharin → HCID 131718561, compound

HRID 1729038Notes

Reaction equation

HRID 1729038 reaction equation
[C:1]([C:5]1[CH:14]=[C:13]2[C:8]([CH2:9][CH:10]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:18][CH:17]=3)[N:11]([CH3:15])[CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[S:26]1([C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:30](=[O:31])[NH:29]1)(=[O:28])=[O:27]>CO>[S:26]1([C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:30](=[O:31])[NH:29]1)(=[O:27])=[O:28].[C:1]([C:5]1[CH:14]=[C:13]2[C:8]([CH2:9][CH:10]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:18][CH:17]=3)[N:11]([CH3:15])[CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 5143SaccharinHCID 21754773HCID 21754773, compound

Product 1

HCID 131718561HCID 131718561, compoundYield 105.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 10 ml of methanol, 0.20 g of 7-tert-butyl-3-(4-tert-butylphenyl)-2-methyl-l,2,3,4-tetrahydroisoquinoline and 0.10 g of saccharin were dissolved under stirring at room temperatureand the resulting mixture was left to stand for 6 hours. The solvent was evaporated under reduced pressure to obtain 0.30 g of 7-tert-butyl-3-(4-tert-butylphenyl)-2-methyl-l,2,3,4-tetrahydroisoquinoline saccharin salt.

Workup

  1. waitwas left
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-63b75cbbd6b44226842997cdf00f1609
Source dataset
uspto-grants-1994_07
Patent number
US05330991

Reaction notes

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