Lithium Hydroxide → HCID 18653794, compound

HRID 1729087Notes

Reaction equation

HRID 1729087 reaction equation
C[O:2][C:3](=[O:39])[C@:4]([CH3:38])([CH2:19][CH:20]1[CH2:26][N:25]=[C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:23]2[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=2[N:21]1[CH3:37])[NH:5][C:6]([O:8][CH:9]1[CH:16]2[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:18][CH:10]1[CH2:11]3)[CH2:15]2)=[O:7].[OH-].[Li+]>O1CCOCC1.O>[CH:10]12[CH2:18][CH:14]3[CH2:13][CH:12]([CH2:17][CH:16]([CH2:15]3)[CH:9]1[O:8][C:6]([NH:5][C@:4]([CH3:38])([C:3]([OH:39])=[O:2])[CH2:19][CH:20]1[CH2:26][N:25]=[C:24]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:23]3[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=3[N:21]1[CH3:37])=[O:7])[CH2:11]2

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 18653795HCID 18653795, compound

Product 1

HCID 18653794HCID 18653794, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of N-[(2-adamantyloxy)carbonyl]-β-(2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-yl )-α-methyl-alanine methyl ester (diastereomeric mixture, 5.3 g, 10 mmol) in a mixture of 150 mL dioxane and 75 mL water was added lithium hydroxide (0.72 g, 30 mmol).

Sources & evidence

ORD record
ord-47d950367dc648b2ade0fa760c6a64b3
Source dataset
uspto-grants-1994_07
Patent number
US05331006

Reaction notes

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