反应详情

In 20 ml of anhydrous tetrahydrofuran were suspended 0.68 g of 2-methoxy-4-nitrophenol, 1.0 g of 1,3-dimethyl-6-[4-(3 -hydroxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound a) and 1.1 g of triphenylphosphine, and 0.71 ml of diethyl azodicarboxylate was added to the resultant suspension. Afterward, the mixture was treated in the same manner as in Reference Example 4, followed by recrystallizing from methanol to obtain 1.35 g of oily 1,3-dimethyl-6-[4-(3-[2-methoxy-4-nitrophenyloxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound w).

1. additionAfterward, the mixture was treated in the same manner as in Reference Example 4
2. customby recrystallizing from methanol