4-Chlorophenol → HCID 19011807, compound

HRID 1729306Notes

Reaction equation

[Cl:1]C1C=CC(O)=CC=1.ClC1C=C(O)C=CC=1.[CH3:17][N:18]1[C:23]([N:24]2[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32][O:33][C:34]3[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[CH:35]=3)[CH2:26][CH2:25]2)=[CH:22][C:21](=[O:41])[N:20]([CH3:42])[C:19]1=[O:43]>>[ClH:1].[CH3:17][N:18]1[C:23]([N:24]2[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32][O:33][C:34]3[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[CH:35]=3)[CH2:26][CH2:25]2)=[CH:22][C:21](=[O:41])[N:20]([CH3:42])[C:19]1=[O:43]

Participants

Reactant 3

HCID 46844-Chlorophenol

HCID 79333-Chlorophenol

HCID 10385868HCID 10385868, compound

Product 1

HCID 19011807HCID 19011807, compound

Procedure

The same treatment as in Example 3 was effected except that 4-chlorophenol was replaced with 3-chlorophenol, thereby obtaining 17.5 g of the crystals of 1,3-dimethyl-6-[4-(3-[3-chlorophenoxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Sources & evidence

ORD record: ord-4ebb903b5aca4bed9623e756c7c3cb99
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332739

Reaction notes

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