Sodium Hydroxide → HCID 19012447, compound

HRID 1729333Notes

Reaction equation

HRID 1729333 reaction equation
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([O:29]C)=[O:28])=[O:19])=[CH:14][CH:13]=2)[C:9](=[O:31])[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>C1COCC1>[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([OH:29])=[O:28])=[O:19])=[CH:14][CH:13]=2)[C:9](=[O:31])[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19012413HCID 19012413, compound

Product 1

HCID 19012447HCID 19012447, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 404 mg of 6-butyl-1-[4-(2-methoxycarbonylanilinocarbonyl)benzyl]-1,2-dihydro-2-oxopyridine, 10 ml of 0.1N aqueous NaOH solution and 17 ml of THF is left to stand for 48 hours at 20°. The THF is evaporated off, the residue is acidified with HCl and extracted with methylene chloride and the extract is dried over Na2SO4 to give 6-butyl-1-[4-(2-carboxyanilinocarbonyl)benzyl]-1,2-dihydro-2-oxopyridine after evaporation.

Workup

  1. waitis left
  2. customThe THF is evaporated off
  3. extractionextracted with methylene chloride
  4. dry with materialthe extract is dried over Na2SO4

Sources & evidence

ORD record
ord-3d7dca667b2f41d8a03f65682e7b9bb0
Source dataset
uspto-grants-1994_07
Patent number
US05332750

Reaction notes

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