Hydroxyamine hydrochloride → HCID 86747994, compound

HRID 1729360Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:19]2([O:25][CH3:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:5]=[C:6]([S:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[C:14](=O)[CH:13]=[CH:12]3)[CH:7]=1.Cl.[NH2:28][OH:29]>>[F:1][C:2]1[CH:3]=[C:4]([C:19]2([O:25][CH3:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:5]=[C:6]([S:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[C:14](=[N:28][OH:29])[CH:13]=[CH:12]3)[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996205HCID 18996205, compound

Product 1

HCID 86747994HCID 86747994, compoundYield 43%

Procedure

Using an analogous procedure to that described in Example 50, 5-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]inden-1-one was reacted with hydroxylamine hydrochloride to give 5-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]inden-1-one oxime in 43% yield, m.p. 124°-136° C., as a 11:9 mixture of the (E)- and (Z)-isomers;

Sources & evidence

ORD record: ord-7eb4c39e6ef84bcba39c572db7b4a25e
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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